坪山中心化学部设计了质子迁移催化（proton-shuttling catalysis，即质子的空间调控）新策略，实现一系列高度不对称反应，进而设计多位点催化中间体参与选择性质子化（multi-site catalytic species，即质子的时间调控），解锁一系列未知的化学反应。并在此基础上将质子选择性迁移概念应用于其他基团的迁移反应中，为重要的药物片段及骨架的合成提供新的思路和技术手段。主要研究方向包括：(1) 质子迁移催化剂的开发；(2) 多位点反应活性中间体的研究；(3) 基团迁移反应的研究；(4) 合成方法学应用于靶向抗肿瘤、代谢性疾病、传染性疾病的药物化学研究。
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