坪山中心化学部设计了质子迁移催化(proton-shuttling catalysis,即质子的空间调控)新策略,实现一系列高度不对称反应,进而设计多位点催化中间体参与选择性质子化(multi-site catalytic species,即质子的时间调控),解锁一系列未知的化学反应。并在此基础上将质子选择性迁移概念应用于其他基团的迁移反应中,为重要的药物片段及骨架的合成提供新的思路和技术手段。主要研究方向包括:(1) 质子迁移催化剂的开发;(2) 多位点反应活性中间体的研究;(3) 基团迁移反应的研究;(4) 合成方法学应用于靶向抗肿瘤、代谢性疾病、传染性疾病的药物化学研究。

科研动态

2024-04-06

2024-Chem Sci-tri-Substituted Oxazoles

Xingchen Ye, Huaijin Pan, Yong Huang, * Jiean Chen * and Zhaofeng Wang *, Chem. Sci. 2024, DOI:10.1039/D4SC01355G.

2024-01-16

2024-Nat Commun-Amide C–N Bonds Activation

Yuxing Cai, Yuxin Zhao, Kai Tang, Hong Zhang, Xueling Mo, Jiean Chen* and Yong Huang*,Nat. Commun. 2024, 15, 496. DOI: 10.1038/s41467-024-44756-8.

2023-10-24

2023-iScience-Ni-Au Electrocatalysis

Zhixin Li‡, Yan Zhang‡, Qianqian Yang, Jindong Wu, Zhi Ren, Fengzhan Si, Jing Zhao* andJiean Chen*,iScience 2023, 26, 107994.

2023-08-08

2023-Adv Sci-Enantioselective SN2 Alkylation of Homoenolates

En Li,Kai Tang,Zhuhui Ren,Xiaoyun Liao,Qianchen Liu,Yong Huang* andJiean Chen*,Adv. Sci.2023, DOI:10.1002/advs.202303517.

2023-05-24

2023-JACS-Csp3-Csp3 Bond Cleavage in Aromatic Hydrocarbons

Ke Liao, Cho Ying Chan, Siqi Liu, Xinhao Zhang, Jiean Chen* and Yong Huang*,J. Am. Chem. Soc. 2023, DOI:10.1021/jacs.3c02745.

2023-04-14

2023-Nat Commun-Hierarchical graph learning for protein–protein interaction

Gao, Z., Jiang, C., Zhang, J.et al.Hierarchical graph learning for protein–protein interaction.Nat. Commun.14, 1093 (2023).https://doi.org/10.1038/s41467-023-36736-1

2023-01-03

2023-Synlett-Addition of Alcohols onto Heteroarenium Salts

Baoli Chen§, En Li§, Feifei Song, Nicolas Guimond, Jiean Chen* and Yong Huang*, Synlett, 2023, DOI: 10.1055/a-2005-5372.

2022-12-05

2022-CS-Thiol-sulfoxonium Ylide Photo-click Reaction

Chuan Wan,†Zhanfeng Hou,†Dongyan Yang,†Ziyuan Zhou,Hongkun Xu,Yuena Wang,ChuanDai,Mingchan Liang,Jun Meng,Jiean Chen,Feng Yin,*Rui Wang*and Zigang Li*,Chem. Sci.,2022, DOI: 10.1039/D2SC05650J.

2022-08-31

2022-Angew-Cross-Coupling of Allyl Halides and Arylboronic Acids

Jingwei Xu, Zhiqi He, Jiwei Zhang, Jiean Chen* and Yong Huang*,Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202211408

2022-08-07

2022-CC-β-Disubstituted Enals with Benzoyl Cyanides

Wangsheng Liu,† Linrui Zhang,† Xiaoyun Liao, Jiean Chen* and Yong Huang*, Chem. Commun, 2022, DOI: 10.1039/D2CC04025E.

2022-06-28

2022-CS-Histidine-Specific Bioconjugation

Chuan Wan, Yuena Wang, Chenshan Lian, Qi Chang, Yuhao An, Jiean Chen, Jinming Sun, Zhanfeng Hou, Dongyan Yang, Xiaochun Guo, Feng Yin,* Rui Wang* and Zigang Li*, Chem. Sci., 2022, DOI: 10.1039/D2SC02353A.

2022-06-02

2022-CC-Enantioselective Synthesis of Acyclic Monohydrosilanes

Delong Mu, Shuqiong Pan, Xiaoyu Wang, Xiaoyun Liao, Yong Huang* and Jiean Chen*, Chem. Commun., 2022, 58, DOI: 10.1039/D2CC02307E

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