坪山中心化学部设计了质子迁移催化（proton-shuttling catalysis，即质子的空间调控）新策略，实现一系列高度不对称反应，进而设计多位点催化中间体参与选择性质子化（multi-site catalytic species，即质子的时间调控），解锁一系列未知的化学反应。并在此基础上将质子选择性迁移概念应用于其他基团的迁移反应中，为重要的药物片段及骨架的合成提供新的思路和技术手段。主要研究方向包括：(1) 质子迁移催化剂的开发；(2) 多位点反应活性中间体的研究；(3) 基团迁移反应的研究；(4) 合成方法学应用于靶向抗肿瘤、代谢性疾病、传染性疾病的药物化学研究。
2024-10-16
Shisheng Huang, Jilong Luo, Ping Chen,Jiean Chen * and Zhaofeng Wang *,Chem. Sci.2024,DOI: 10.1039/D4SC06166G.
2024-08-03
En Li‡, Xiaoyun Liao‡, Fangfang Guo‡, Yong Huang* and Jiean Chen*,Org. Lett. 2024, DOI:10.1021/acs.orglett.4c02082
2024-07-25
Ke Liao, Yuqi Fang, Lei Sheng, Jiean Chen * and Yong Huang *,Nat. Commun.2024, 15, 6227.
2024-05-13
Yan Zhang, Jindong Wu, Xinrui Zhu, Zhi Ren* and Jiean Chen*,Appl. Catal. B, 2024, 354, 124093.
2024-04-06
Xingchen Ye, Huaijin Pan, Yong Huang, * Jiean Chen * and Zhaofeng Wang *, Chem. Sci. 2024, DOI:10.1039/D4SC01355G.
2024-01-16
Yuxing Cai, Yuxin Zhao, Kai Tang, Hong Zhang, Xueling Mo, Jiean Chen* and Yong Huang*,Nat. Commun. 2024, 15, 496. DOI: 10.1038/s41467-024-44756-8.
2023-10-24
Zhixin Li‡, Yan Zhang‡, Qianqian Yang, Jindong Wu, Zhi Ren, Fengzhan Si, Jing Zhao* andJiean Chen*,iScience 2023, 26, 107994.
2023-08-08
En Li,Kai Tang,Zhuhui Ren,Xiaoyun Liao,Qianchen Liu,Yong Huang* andJiean Chen*,Adv. Sci.2023, DOI:10.1002/advs.202303517.
2023-05-24
Ke Liao, Cho Ying Chan, Siqi Liu, Xinhao Zhang, Jiean Chen* and Yong Huang*,J. Am. Chem. Soc. 2023, DOI:10.1021/jacs.3c02745.
2023-04-14
Gao, Z., Jiang, C., Zhang, J.et al.Hierarchical graph learning for protein–protein interaction.Nat. Commun.14, 1093 (2023).https://doi.org/10.1038/s41467-023-36736-1
2023-01-03
Baoli Chen§, En Li§, Feifei Song, Nicolas Guimond, Jiean Chen* and Yong Huang*, Synlett, 2023, DOI: 10.1055/a-2005-5372.
2022-12-05
Chuan Wan,†Zhanfeng Hou,†Dongyan Yang,†Ziyuan Zhou,Hongkun Xu,Yuena Wang,ChuanDai,Mingchan Liang,Jun Meng,Jiean Chen,Feng Yin,*Rui Wang*and Zigang Li*,Chem. Sci.,2022, DOI: 10.1039/D2SC05650J.
