坪山中心化学部设计了质子迁移催化（proton-shuttling catalysis，即质子的空间调控）新策略，实现一系列高度不对称反应，进而设计多位点催化中间体参与选择性质子化（multi-site catalytic species，即质子的时间调控），解锁一系列未知的化学反应。并在此基础上将质子选择性迁移概念应用于其他基团的迁移反应中，为重要的药物片段及骨架的合成提供新的思路和技术手段。主要研究方向包括：(1) 质子迁移催化剂的开发；(2) 多位点反应活性中间体的研究；(3) 基团迁移反应的研究；(4) 合成方法学应用于靶向抗肿瘤、代谢性疾病、传染性疾病的药物化学研究。
2025-05-06
Yan Zhang, Xinrui Zhu, Jindong Wu, Zhipeng Liao, Sanyangzi Liao, Zexin Jiang, Yaofeng Li, Zhi Ren,* and Jiean Chen*,Int J Hydrogen Energy, 2025, 133,320-328.
2025-05-06
Yan Zhang, Xinrui Zhu, Jindong Wu, Zexin Jiang, Yaofeng Li, Sanyangzi Liao, Zhipeng Liao, Zhi Ren,* and Jiean Chen*,Adv. Energy Sustainability Res. 2025, 2500051.
2025-05-06
Delong Mu,* Xinrui Zhu, and Jiean Chen*,Org. Lett. 2025,27, 3622–3630
2025-05-06
Delong Mu,* Xinrui Zhu and Jiean Chen*,Chem. Commun. 2025, DOI:10.1039/d5cc00967g.
2025-01-06
Chenran Jiang,* Yuxin Ye, Wei Kang, Jinglei Yang, Zhipeng He, Qixiong Cao, Chenshan Lian,Yajie Xing, Qianqian Yang, Juan Zhao, Shuqiong Pan, Meixi Feng, Chunli Song, Zhihong Liu, Rui Wang, Feng Yin, Yun-Dong Wu,* Jiean Chen* and Yong Huang*···
2025-01-05
Yan Zhang, Xinrui Zhu,Jindong Wu, Zhipeng Liao, Shuo Song, Zhi Ren* and Jiean Chen*,J. Colloid Interface Sci.,2025,683, 964–972.
2024-10-16
Shisheng Huang, Jilong Luo, Ping Chen,Jiean Chen * and Zhaofeng Wang *,Chem. Sci.2024,DOI: 10.1039/D4SC06166G.
2024-08-03
En Li‡, Xiaoyun Liao‡, Fangfang Guo‡, Yong Huang* and Jiean Chen*,Org. Lett. 2024, DOI:10.1021/acs.orglett.4c02082
2024-07-25
Ke Liao, Yuqi Fang, Lei Sheng, Jiean Chen * and Yong Huang *,Nat. Commun.2024, 15, 6227.
2024-05-13
Yan Zhang, Jindong Wu, Xinrui Zhu, Zhi Ren* and Jiean Chen*,Appl. Catal. B, 2024, 354, 124093.
2024-04-06
Xingchen Ye, Huaijin Pan, Yong Huang, * Jiean Chen * and Zhaofeng Wang *, Chem. Sci. 2024, DOI:10.1039/D4SC01355G.
2024-01-16
Yuxing Cai, Yuxin Zhao, Kai Tang, Hong Zhang, Xueling Mo, Jiean Chen* and Yong Huang*,Nat. Commun. 2024, 15, 496. DOI: 10.1038/s41467-024-44756-8.
